Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital
Authors:
Monira Taha Ismail,
Walaa Adel Siam,
Gamela Mohamed Nasr,
Mohamed Shaaban Elsakaya
Background: Heart-type fatty acid-binding protein (H-FABP) is a new biochemical marker which is recently being used in the early diagnosis of acute coronary syndrome (ACS) in the early phase at 0-3 hours of chest pain onset. The aim of this study was to diagnose ACS patients early in the ER using H-FABP in the early stage during 0-3 hours of chest pain. Methods: This is a cross-sectional descriptive study that included 41 ACS patients who presented to the emergency department of the Suez Canal University Hospital, who fulfilled the inclusion and exclusion criteria. Results: Out of the 41 patients of ACS, 26 were male and 15 were female with a mean age of 56.8 ± 12.9 years. It was found that H-FABP was elevated in 68.3% of the patients at 0-3 hours of chest pain which increased to 80.5% at 3-6 hours of chest pain onset with 76.2% sensitivity at 0-3 hours which increased to 85.7% at 3-6 hours, while specificity was 70% at 0-3 hours but increased at 3-6 hours. The receiver operating characteristic curve was performed to find out the best cut-off value of H-FABP at 0-3 hours and at 3-6 hours' interval which was 19 ng/l for diagnosis of acute MI (ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction). Conclusion: H-FABP is a promising cardiac biomarker for the early identification of myocardial ischemia and infarction. It could be a superior biomarker for earlier detection of ACS.
Keywords: Acute coronary syndrome, chest pain, heart-type fatty acid-binding protein, myocardial infarction.
Authors
Monira Taha Ismail
Faculty of Medicine, Suez Canal University, Ismailia, Egypt & Associate Professor of Emergency Medicine, Medical Science Department, Sulaiman Al-Rajhi University, Saudi Arabia
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Correspondence to:
Monira Taha Ismail, Assistant Professor of Emergency Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt & Associate Professor of Emergency Medicine, Medical Science Department, Sulaiman Al-Rajhi University, Saudi Arabia monirataha77@yahoo.com
Publication history:
Received 15 May 2020
Revised 24 Aug 2020
Accepted 24 Jan 2021
Published online 24 Apr 2021
Published in print 30 May 2021
Ismail MT, Siam WA, Nasr GM, Elsakaya MS. Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital. SJEMed. 2021; 2(2): 160-165. doi:
10.24911/SJEMed/72-1589536093
Ismail MT, Siam WA, Nasr GM, Elsakaya MS. Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital. https://sjemed.com/?mno=107395 [Access: November 29, 2024]. doi:
10.24911/SJEMed/72-1589536093
Ismail MT, Siam WA, Nasr GM, Elsakaya MS. Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital. SJEMed. 2021; 2(2): 160-165. doi:
10.24911/SJEMed/72-1589536093
Ismail MT, Siam WA, Nasr GM, Elsakaya MS. Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital. SJEMed. (2021), [cited November 29, 2024]; 2(2): 160-165. doi:
10.24911/SJEMed/72-1589536093
Ismail, M. T., Siam, . W. A., Nasr, . G. M. & Elsakaya, . M. S. (2021) Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital. SJEMed, 2 (2), 160-165. doi:
10.24911/SJEMed/72-1589536093
Ismail, Monira Taha, Walaa Adel Siam, Gamela Mohamed Nasr, and Mohamed Shaaban Elsakaya. 2021. Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital. Saudi Journal of Emergency Medicine, 2 (2), 160-165. doi:
10.24911/SJEMed/72-1589536093
Ismail, Monira Taha, Walaa Adel Siam, Gamela Mohamed Nasr, and Mohamed Shaaban Elsakaya. "Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital." Saudi Journal of Emergency Medicine 2 (2021), 160-165. doi:
10.24911/SJEMed/72-1589536093
Ismail, Monira Taha, Walaa Adel Siam, Gamela Mohamed Nasr, and Mohamed Shaaban Elsakaya. "Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital." Saudi Journal of Emergency Medicine 2.2 (2021), 160-165. Print. doi:
10.24911/SJEMed/72-1589536093
Ismail, M. T., Siam, . W. A., Nasr, . G. M. & Elsakaya, . M. S. (2021) Diagnostic value of heart-type fatty acidbinding protein in the early diagnosis of acute coronary syndrome at the Emergency Medicine Department of Suez Canal University Hospital. Saudi Journal of Emergency Medicine, 2 (2), 160-165. doi:
10.24911/SJEMed/72-1589536093