Background: Massive pulmonary embolism (PE) is a deadly disease that can be managed by thrombolytic therapy to save patients' lives. A case of postpartum woman Who presented to the emergency department (ED) with cardiac arrest due to massive PE. Case presentation: We report a case of 34-year-old woman who presented to the ED with cardiac arrest due to massive PE 2 weeks post-uncomplicated spontaneous vaginal delivery. She was managed by a comprehensive multidisciplinary team approach, cardio-cerebral resuscitation (CCR), and systemic thrombolysis. The thrombolysis resulted in massive vaginal bleeding, which led to a prolonged cardiac arrest. This was recognized timely and managed adequately. The patient survived and was discharged home with a good neurological and cardiovascular outcome. Conclusion: Vaginal bleeding may occur post thrombolysis in post-partum life-threatening PE, which can be resolved by a multidisciplinary team-based approach coupled with CCR.

Keywords: Pulmonary Embolism, Thrombolysis, Team approach, Cardio-cerebral resuscitation.