Background: Cantharidin, a toxic substance produced by Meloidae (Coleoptera family) beetles, poses serious health risks upon ingestion, including renal impairment, hematemesis, altered consciousness, electrolyte imbalances, and hematuria. Case Report: This study presents two pediatric cases of cantharidin poisoning resulting from biting of Meloid beetles. Case 1 involved a 2-year-old exhibiting hematuria and vomiting, while case 2, a 9-month-old, presented with agitation, lethargy, and hematuria. Both cases required intensive care and supportive management. Conclusion: These cases highlight the clinical manifestations of cantharidin intoxication in children following exposure to Meloid beetles. Early recognition of symptoms, prompt medical intervention, and close monitoring are crucial in managing cantharidin poisoning, for which no specific antidote currently exists.

Keywords: Cantharidin, Intoxication, Meloidae, Paediatric, Blister beetle, Case report, Saudi Arabia