Background: Cardioversion is the treatment of choice in an unstable patient with arrhythmia. It requires analgesia and sedation, which is usually given via intravenous route. However, when there is a failure to get vascular access, alternatives routes to intravenous (IV) sedation and analgesia are needed. Case Presentation: A 59 year old male patient was presented to the emergency department (ED) complaining of chest pain and palpitation. His electrocardiogram (ECG) showed new onset rapid narrow complex atrial fibrillation, which then converted to wide complex tachycardia. Initially, the patient remained hemodynamically stable, but his blood pressure dropped, when cardioversion was indicated. In this case, intranasal (IN) and intraosseous (IO) routes were used, both of which are uncommon to be used for sedation in an unstable patient. The sedatives bioavailability and dosage via non intravenous (non-IV) routes are not commonly used, hence, literature was reviewed to find out the appropriate sedative dosage via non-IV routes specifically in IN and IO route for moderate sedation in ED, to facilitate procedures like cardioversion. Conclusion: It was believed that IN and IO routes are good alternatives to intravenous routes when timely vascular access can’t be secured and when emergency medication administration is required.

Keywords: Non-IV route in resuscitation, Intraosseous access, Intra nasal route for sedative administration, sedative bioavailability, procedural sedation, analgesia.